Eline Claire Grosfeld

Colophon The work described in this thesis was performed at the Department of Dentistry, Regenerative Biomaterials group, of the Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. The research presented in this thesis was supported by the Army, Navy, NIH, Air Force, VA and Health Affairs to support the AFIRM II effort, under Award No. W8NXWH-14-2-0004. The U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick, MD 21702–5014 is the awarding and administering acquisition office. Opinions, interpretations, conclusions and recommendations are those of the author(s) and are not necessarily endorsed by the Department of Defense. Ceramic powder was kindly provided by CAM Bioceramics B.V. Playing with porogens to render injectable calcium phosphate cements degradable Cover design: Ron Zijlmans || www.ron.nu Layout: Dennis Hendriks || ProefschriftMaken.nl Printed by: ProefschriftMaken.nl ISBN/EAN: 978-94-6469-912-8 Copyright© Eline-Claire Grosfeld, 2024 All rights reserved. No parts of this publication may be reproduced, stored in a retrieval system, or transmitted by any form or by any means, without the permission in writing from the author. Playing with porogens to render injectable calcium phosphate cements degradable Proefschrift ter verkrijging van de graad van doctor aan de Radboud Universiteit Nijmegen op gezag van de rector magnificus prof. dr. J.M. Sanders, volgens besluit van het college voor promoties in het openbaar te verdedigen op woensdag 3 juli 2024 om 10.30 uur precies door Eline-Claire Grosfeld geboren op 27 mei 1987 te Velsen Promotoren: Prof. dr. J.A. Jansen, Dr. ing. J.J.J.P. van den Beucken Copromotor: Dr. J.W.M. Hoekstra Manuscriptcommissie: Prof. dr. B.W. Schreurs, Dr. D. Gawlitta (Universitair Medisch Centrum Utrecht), Dr. J.C.H. Leijten (Universiteit Twente) Paranimfen: Winston Camargo, Mark van den Tempel Playing with porogens to render injectable calcium phosphate cements degradable Dissertation to obtain the degree of doctor from Radboud University Nijmegen on the authority of the Rector Magnificus prof. dr. J.M. Sanders, according to the decision of the Doctorate Board to be defended in public on Wednesday, July 3, 2024 at 10:30 am by Eline-Claire Grosfeld born on May 27, 1987 in Velsen (The Netherlands) PhD supervisors: Prof. dr. J.A. Jansen, Dr. ing. J.J.J.P. van den Beucken PhD co-supervisor: Dr. J.W.M. Hoekstra Manuscript Committee: Prof. dr. B.W. Schreurs, Dr. D. Gawlitta (University Medical Center Utrecht), Dr. J.C.H. Leijten (University of Twente) Paranymphs: Winston Camargo, Mark van den Tempel Contents Chapter 1 General introduction and objectives of this thesis Chapter 2 Long-term biological performance of injectable and degradable calcium phosphate cement Chapter 3 Multimodal porogen platforms for calcium phosphate cement degradation Chapter 4 Incorporation of fast dissolving glucose porogens into an injectable calcium phosphate cement for bone tissue engineering Chapter 5 Fast dissolving glucose porogens for early calcium phosphate cement degradation and bone regeneration Chapter 6 Evaluating the orthotopic performance of calcium phosphate cement/poly(lactic-co-glycolic acid) with compositional variations in calcium phosphate cement and poly(lactic-co-glycolic acid) porogens Summary and address to the aims Closing remarks and future perspectives