{"id":8887,"date":"2026-04-07T09:18:53","date_gmt":"2026-04-07T09:18:53","guid":{"rendered":"https:\/\/www.proefschriftmaken.nl\/portfolio\/manon-van-oosten\/"},"modified":"2026-04-23T08:31:16","modified_gmt":"2026-04-23T08:31:16","slug":"manon-van-oosten","status":"publish","type":"us_portfolio","link":"https:\/\/www.proefschriftmaken.nl\/en\/portfolio\/manon-van-oosten\/","title":{"rendered":"Manon Van Oosten"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":8,"featured_media":13631,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"us_portfolio_category":[45],"class_list":["post-8887","us_portfolio","type-us_portfolio","status-publish","has-post-thumbnail","hentry","us_portfolio_category-new-template"],"acf":{"naam_van_het_proefschift":"The use of health claims data for epidemiology and costs of chronic kidney disease","samenvatting":"Er is geen Nederlandse samenvatting beschikbaar. De Engelse samenvatting vind je <a href=\"https:\/\/www.proefschriftmaken.nl\/en\/portfolio\/manon-van-oosten\/\">hier<\/a>.","summary":"Chronic kidney disease (CKD) is considered a major public health problem due to its negative impact on a patients\u2019 quality of life and life expectancy and its association with high healthcare costs and healthcare utilization. A better understanding of CKD, its treatment, and outcomes is essential to improve healthcare for CKD patients. Health claims data is a relatively new source of data that offers new research opportunities for large populations of patients with kidney disease and health outcomes in a non-experimental setting. Despite the growing international popularity of health claims data, so far the use of health claims data for kidney research in the Netherlands was still in its infancy.\n\nThis thesis examines the possibilities of Dutch health claims data (stored in the Vektis database) for research in advanced CKD patients, being Stage G4-G5 CKD patients without kidney replacement therapy (KRT) and Stage G5 CKD patients with KRT (i.e. dialysis or kidney transplantation). The first aim of this thesis was to examine the value and limitations of health claims data for kidney research. The second aim was to study healthcare expenditure and use of healthcare resources (including medication use) of CKD patients using Dutch health claims data.\n\nThis thesis consists of four parts: part 1 provides insight into the value and use of health claims data for kidney research, part 2 describes the validity of Dutch health claims data for the identification of CKD patients, and parts 3 and 4 describe the use of health claims data for measuring healthcare costs and medication use of CKD patients. The content of this thesis is summarized below.\n\nPart 1 \u2013 Value and use of health claims data for kidney research\nChapter 2 provides an overview of international health claims databases that were used for kidney research. With a literature search, we identified 13 of such health claims databases in 10 countries. We discussed the similarities and distinctions between the databases, the differences in accessibility, the main publications in the area of nephrology, and highlighted the Dutch health claims database. Further, we discussed the strengths and limitations of health claims data. Finally, we introduced the online Dutch Kidney Atlas which was developed with the research presented in this thesis. This website is an innovative way of describing Dutch CKD patients based on health claims data. It describes the burden of CKD in the Netherlands, in terms of numbers of patients, healthcare expenditures, treatment (besides KRT), medication, outcomes, and other conditions associated with CKD and outlines the geographical variation per region in the Netherlands.\n\nPart 2 \u2013 Validity of Dutch health claims data\nValidation studies help to understand whether the studied populations derived from health claims databases are representative of the entire population of interest and which subgroups may be underrepresented or overrepresented. Chapter 3 describes the results of a validation study in which we tested the validity of Dutch health claims data from a regional hospital in Zwolle in identifying CKD Stages G3-G5 patients using a laboratory database as a reference. We compared a claim-based diagnosis of CKD (Stages G3-G5) and advanced CKD (Stage G4-G5) with one based on eGFR definitions of CKD (eGFR <60 mL\/min\/1.73 m2) and advanced CKD (eGFR <30 mL\/min\/1.73 m2). Analyses were stratified by age and sex. Sensitivity was higher in advanced CKD patients (51%) than in CKD patients (27%). Moreover, the validity of claims data in identifying CKD patients was remarkably higher in young patients compared with elderly patients and higher in men than in women. This validation study demonstrated that Dutch health claims data have low sensitivity for the estimation of overall CKD prevalence in the general population, especially in the case of elderly CKD patients and patients with less advanced CKD. Nonetheless, health claims data may have value in estimating CKD prevalence in specific subgroups, particularly in young patients and those with advanced CKD.","auteur":"Manon Van Oosten","auteur_slug":"manon-van-oosten","publicatiedatum":"1 april 2022","taal":"NL","url_flipbook":"https:\/\/ebook.proefschriftmaken.nl\/ebook\/manonvanoosten?iframe=true","url_download_pdf":"","url_epub":"","ordernummer":"FTP-202604070915","isbn":"978-94-6423-720-7","doi_nummer":"","naam_universiteit":"Universiteit van Amsterdam","afbeeldingen":13631,"naam_student:":"","binnenwerk":"","universiteit":"Universiteit van Amsterdam","cover":"","afwerking":"","cover_afwerking":"","design":""},"_links":{"self":[{"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/us_portfolio\/8887","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/us_portfolio"}],"about":[{"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/types\/us_portfolio"}],"author":[{"embeddable":true,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/comments?post=8887"}],"version-history":[{"count":1,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/us_portfolio\/8887\/revisions"}],"predecessor-version":[{"id":8888,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/us_portfolio\/8887\/revisions\/8888"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/media\/13631"}],"wp:attachment":[{"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/media?parent=8887"}],"wp:term":[{"taxonomy":"us_portfolio_category","embeddable":true,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/us_portfolio_category?post=8887"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}