{"id":11654,"date":"2026-04-13T12:50:27","date_gmt":"2026-04-13T12:50:27","guid":{"rendered":"https:\/\/www.proefschriftmaken.nl\/portfolio\/yuyi-wong\/"},"modified":"2026-05-01T13:27:45","modified_gmt":"2026-05-01T13:27:45","slug":"yuyi-wong","status":"publish","type":"us_portfolio","link":"https:\/\/www.proefschriftmaken.nl\/en\/portfolio\/yuyi-wong\/","title":{"rendered":"Yuyi Wong"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":8,"featured_media":14710,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"us_portfolio_category":[45],"class_list":["post-11654","us_portfolio","type-us_portfolio","status-publish","has-post-thumbnail","hentry","us_portfolio_category-new-template"],"acf":{"naam_van_het_proefschift":"MOVING FORWARD ON ACQUIRED DEMYELINATING SYNDROMES","samenvatting":"fdstuk 3.9 hebben 24 nieuw gediagnosticeerde kinderen met MS een uitgebreide urologische screening gekregen inclusief uroflowmetrie, waarbij tegelijkertijd een (niet-invasieve) elektromyografie van de bekkenbodemspieren werd verricht. Een groot aantal kinderen had reeds mictieproblemen in de eerste 18 maanden na diagnose (21%). Mictievragenlijsten waren voldoende om 80% van de pati\u00ebnten met een neurogene blaas te detecteren; \u00e9\u00e9n pati\u00ebnt zou gemist zijn wanneer deze kinderen niet systematisch werden doorverwezen voor de urologische screening. Artsen die kinderen met MS behandelen dienen alert te zijn op het voorkomen van neurogeen blaaslijden vroeg in het ziektebeloop.\n\nDe verandering van MRI lesies tijdens follow-up van ADEM pati\u00ebnten is weinig onderzocht. In hoofdstuk 3.10 werden 42 kinderen met een ADEM ge\u00efncludeerd voor analyse. Bij ADEM kinderen die \u22652 MRI scans hadden in de acute fase (eerste 3 maanden na het ontstaan van klachten) en \u22651 scan na de acute fase zagen we dat de veranderingen van MRI afwijkingen achterloopt ten opzichte van de klinische symptomen: in 3\/42 pati\u00ebnten was de MRI normaal bij debuut (MRI verricht 3, 7 en 30 dagen na onset) en werden MRI afwijkingen zichtbaar op follow-up scans gemaakt op respectievelijk dag 26, 36 en 40. Daarnaast zagen we dat verslechtering van MRI afwijkingen (e.g. toename in grootte van bestaande lesies of ontstaan nieuwe lesies) vaak voorkomt in de acute fase, ondanks verbetering in de kliniek. Toename van afwijkingen (in grootte en\/of aantal) gebeurt zeer zelden na de eerste drie maanden. Derhalve adviseren we 3 maanden na het ontstaan van symptomen een nieuwe MRI te verrichten als nieuwe uitgangswaarde voor eventuele nieuwe aanvallen.\n\nDe belangrijkste bevindingen van onze studies zijn samengevat en bediscussieerd in hoofdstuk 4. Hier worden ook aanbevelingen gedaan voor toekomstig onderzoek.","summary":"In Chapter 3.9, 24 newly diagnosed children with MS underwent extensive urological screening including uroflowmetry, with concurrent (non-invasive) electromyography of the pelvic floor muscles. A large number of children already had micturition problems within the first 18 months after diagnosis (21%). Micturition questionnaires were sufficient to detect 80% of patients with a neurogenic bladder; one patient would have been missed if these children had not been systematically referred for urological screening. Physicians treating children with MS should be alert to the occurrence of neurogenic bladder disease early in the course of the disease.\n\nThe change in MRI lesions during follow-up of ADEM patients has been little studied. In Chapter 3.10, 42 children with ADEM were included for analysis. In ADEM children who had \u22652 MRI scans in the acute phase (first 3 months after onset of symptoms) and \u22651 scan after the acute phase, we observed that changes in MRI abnormalities lag behind clinical symptoms: in 3\/42 patients, the MRI was normal at onset (performed at 3, 7, and 30 days) and abnormalities only became visible on follow-up scans made on days 26, 36, and 40 respectively. Additionally, worsening of MRI abnormalities (e.g., increase in size or new lesions) often occurs during the acute phase despite clinical improvement. An increase in abnormalities rarely occurs after the first three months. Therefore, we recommend performing a new MRI 3 months after the onset of symptoms as a new baseline for future attacks.\n\nThe main findings of our studies are summarized and discussed in Chapter 4, where recommendations for future research are also provided.","auteur":"Yuyi Wong","auteur_slug":"yuyi-wong","publicatiedatum":"12 februari 2019","taal":"NL","url_flipbook":"https:\/\/ebook.proefschriftmaken.nl\/ebook\/yuyiwong?iframe=true","url_download_pdf":"https:\/\/ebook.proefschriftmaken.nl\/download\/43c2637c-7a88-4878-ba3e-c2ffff6fb2dc\/optimized","url_epub":"","ordernummer":"FTP-202604131248","isbn":"978-94-6380-177-5","doi_nummer":"","naam_universiteit":"Erasmus Universiteit Rotterdam","afbeeldingen":14710,"naam_student:":"","binnenwerk":"","universiteit":"Erasmus Universiteit Rotterdam","cover":"","afwerking":"","cover_afwerking":"","design":""},"_links":{"self":[{"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/us_portfolio\/11654","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/us_portfolio"}],"about":[{"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/types\/us_portfolio"}],"author":[{"embeddable":true,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/comments?post=11654"}],"version-history":[{"count":1,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/us_portfolio\/11654\/revisions"}],"predecessor-version":[{"id":11657,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/us_portfolio\/11654\/revisions\/11657"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/media\/14710"}],"wp:attachment":[{"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/media?parent=11654"}],"wp:term":[{"taxonomy":"us_portfolio_category","embeddable":true,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/us_portfolio_category?post=11654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}