{"id":11120,"date":"2026-04-13T07:20:28","date_gmt":"2026-04-13T07:20:28","guid":{"rendered":"https:\/\/www.proefschriftmaken.nl\/portfolio\/dailing-wu\/"},"modified":"2026-04-13T08:31:17","modified_gmt":"2026-04-13T08:31:17","slug":"dailing-wu","status":"publish","type":"us_portfolio","link":"https:\/\/www.proefschriftmaken.nl\/en\/portfolio\/dailing-wu\/","title":{"rendered":"Dailing Wu"},"content":{"rendered":"","protected":false},"excerpt":{"rendered":"","protected":false},"author":7,"featured_media":11121,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"us_portfolio_category":[45],"class_list":["post-11120","us_portfolio","type-us_portfolio","status-publish","has-post-thumbnail","hentry","us_portfolio_category-new-template"],"acf":{"naam_van_het_proefschift":"The Effects of Antimicrobials on Aquatic Ecosystems","samenvatting":"Antimicrobi\u00eble middelen, waaronder antibiotica en biociden, worden op grote schaal gebruikt in de humane en veterinaire geneeskunde, en residuen hiervan worden regelmatig aangetroffen in aquatische milieus. Dit proefschrift onderzoekt het voorkomen, de ecologische effecten en de mitigatie van antimicrobi\u00eble middelen in zoetwatersystemen door middel van een combinatie van milieumonitoring, experimentele microkosmossen en voedselketenstudies.\n\nHoofdstuk 2 onderzocht de verontreinigingspatronen van antibiotica en antibioticaresistentiegenen (ARG's) langs een continu\u00fcm van rivier, sediment en grondwater in de sterk verstedelijkte Maozhou-rivier in China. De studie stelde hoge ecologische risico's vast voor algen en identificeerde dat riviersedimenten de primaire bron waren van ARG-contaminatie in ondiep grondwater, terwijl rivierwater significanter bijdroeg aan dieper grondwater.\n\nHoofdstuk 3 onderzocht de individuele en gecombineerde effecten van sulfamethazine en tetracycline in zoetwater-microkosmossen. De studie toonde aan dat deze antibiotica, wanneer aanwezig als mengsels, niet-additieve effecten kunnen uitoefenen op fytoplankton en microbi\u00eble gemeenschappen, wat de complexiteit benadrukt van het voorspellen van ecologische resultaten op basis van gegevens van enkelvoudige stoffen.\n\nHoofdstuk 4 richtte zich op de biocide triclosan en beoordeelde de impact ervan op de structuur van microbi\u00eble gemeenschappen in verschillende sedimenttypen en nutri\u00ebntenregimes. De resultaten lieten zien dat de omvang van de microbi\u00eble respons op triclosan sterk wordt be\u00efnvloed door de omgevingscontext, zoals het gehalte aan organische stof en de waterkwaliteit.\n\nHoofdstuk 5 verkende de bioaccumulatie en trofische overdracht van azithromycine in een vereenvoudigde zoetwatervoedselketen. Hoewel er geen biomagnificatie werd waargenomen, toonde de studie subletale effecten aan op de fitheid van predatoren, zoals verminderde groei, wat aangeeft dat de afwezigheid van biomagnificatie ecologisch relevante effecten niet uitsluit.\n\nHoofdstuk 6 evalueerde de ecologische winst behaald met geavanceerde afvalwaterzuiveringsmethoden, zoals bio-actieve koolfiltratie en ozonizatie. De bevindingen lieten zien dat hoewel deze behandelingen de chemische druk effectief verminderen, hun ecologische voordelen moeten worden afgewogen tegen door de behandeling veroorzaakte verschuivingen in nutri\u00ebntenomstandigheden en microbi\u00eble functionele herstructurering.\n\nHoofdstuk 7 synthetiseerde de bevindingen en concludeerde dat de ecologische effecten van antimicrobi\u00eble middelen sterk contextafhankelijk zijn. Het proefschrift pleit voor een ge\u00efntegreerde aanpak die rekening houdt met externe en interne blootstelling, mengseldruk en functionele responsen voor een ecologisch relevanter beheer van zoetwater.","summary":"Antimicrobials, including antibiotics and biocidal agents, are used extensively in human and veterinary medicine, and their residues are frequently detected in aquatic environments. This thesis investigates the occurrence, ecological effects, and mitigation of antimicrobials in freshwater ecosystems through a combination of environmental monitoring, experimental microcosms, and food-chain studies.\n\nChapter 2 examined the pollution patterns of antibiotics and antibiotic resistance genes (ARGs) along a river-sediment-groundwater continuum in the highly urbanised Maozhou River, China. The study found high ecological risks for algae and identified that river sediments were the primary source of ARG contamination in shallow groundwater, whereas river water contributed more significantly to deeper groundwater.\n\nChapter 3 investigated the individual and mixture effects of sulfamethazine and tetracycline in freshwater microcosms. The study demonstrated that these antibiotics, when present as mixtures, can exert non-additive effects on phytoplankton and microbial communities, highlighting the complexity of predicting ecological outcomes from single-compound data.\n\nChapter 4 focused on the antimicrobial biocide triclosan, assessing its impact on microbial community structure across different sediment types and nutrient regimes. The results showed that the magnitude of microbial responses to triclosan is strongly modulated by the environmental context, such as organic matter content and water quality.\n\nChapter 5 explored the bioaccumulation and trophic transfer of azithromycin into a simplified freshwater food chain. Although no biomagnification was observed, the study showed sublethal fitness-related effects in predators, such as reduced growth, indicating that the absence of biomagnification does not exclude ecologically relevant impacts.\n\nChapter 6 evaluated the ecological gain achieved by different advanced wastewater treatment methods from a risk-management perspective by assessing whether reductions in micropollutant pressure are accompanied by concurrent decreases in mixture toxicity and adverse ecological responses. The findings showed that while these treatments effectively reduce chemical pressure, their ecological benefits must be balanced against treatment-driven shifts in resource conditions and microbial functional restructuring.\n\nChapter 7 synthesized cross-chapter findings and discussed implications for ecological risk assessment and freshwater management. Ecological effects of antimicrobials were strongly context-dependent, with response direction and magnitude jointly shaped by exposure composition, environmental background conditions, and trophic level. The thesis supports integrated consideration of external exposure, internal exposure, mixture pressure, and functional ecological responses to inform more ecologically relevant freshwater management.","auteur":"Dailing Wu","auteur_slug":"dailing-wu","publicatiedatum":"8 mei 2026","taal":"EN","url_flipbook":"https:\/\/ebook.proefschriftmaken.nl\/ebook\/dailingwu?iframe=true","url_download_pdf":"https:\/\/ebook.proefschriftmaken.nl\/download\/47862425-3559-4a13-aab0-23e82e033a01\/optimized","url_epub":"","ordernummer":"18656","isbn":"978-94-6534-341-9","doi_nummer":"","naam_universiteit":"Wageningen University","afbeeldingen":11122,"naam_student:":"","binnenwerk":"","universiteit":"Wageningen University","cover":"","afwerking":"","cover_afwerking":"","design":""},"_links":{"self":[{"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/us_portfolio\/11120","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/us_portfolio"}],"about":[{"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/types\/us_portfolio"}],"author":[{"embeddable":true,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/comments?post=11120"}],"version-history":[{"count":1,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/us_portfolio\/11120\/revisions"}],"predecessor-version":[{"id":11123,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/us_portfolio\/11120\/revisions\/11123"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/media\/11121"}],"wp:attachment":[{"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/media?parent=11120"}],"wp:term":[{"taxonomy":"us_portfolio_category","embeddable":true,"href":"https:\/\/www.proefschriftmaken.nl\/en\/wp-json\/wp\/v2\/us_portfolio_category?post=11120"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}